To detect early-stage lung cancer, Chinese scientists have developed an Artificial Intelligence (AI) assisted testing tool. The Lung Cancer Artificial Intelligence Detector may detect an early lung cancer or large-scale screening of high-risk cancer populations, as per the journal in Science Translational Medicine.
The team of scientists from Peking University performed single-cell RNA sequencing of different early-stage lung cancers and found fat metabolism to become abnormal in different cell types.
In the hospital in Beijing, the detector achieved over 90% accuracy in a lung cancer screening group of 1,036 participants undergoing routine CT scans and a group of 109 lung cancer patients.
The scientists enlisted 311 participants including 171 early-stage non-small cell lung cancer patients and 140 healthy people to analyze lipid-related molecules in their plasma. According to the study, most of the diagnosed participants affected with lung cancer were non-smokers with stage one tumors.
As per the study, the scientists selected nine lipids that are deemed most important for early-stage cancer detection using a machine-learning algorithm and built the AI-assisted detection model.
Yin Yuxin, a professor from the School of Basic Medical Sciences of Peking University and the paper’s co-author said the new detection strategy is helpful for the early diagnosis, auxiliary diagnosis, or population screening of many tumor diseases.
In 2021, Yin and his team developed AI-assisted tumor metabolism detection methods for pancreatic cancer and esophageal cancer.
